I'm in Pfizer's COVID vaccine trial, ask me anything.

[Seajay]

Any truth to blood type being less or more resistant?

I had Pfizer 1 and 2, and the first was way worse than the 2nd for me. I passed out on a table. The shot location had soreness but that was it as far as any pain.
I've been tested multiple times since I was vaxed and always negative.

[Diomedes]

We were unblinded when it was approved back in the winter.

[BrickHaus]

Id like to chime back in. I got my second moderna shot last week, and I can honestly say I didnt see any side effects or symptoms with either shot.

I DID suffer a leg cramp in my calf the night of the second dose, but it was also leg day that morning, so I dunno. Im sure the vaccine was a factor in the cramp. But not the only cause. Lol

[un2xs]

Diomedes, when, if ever, will they unblind the trial? You have said that both of you are sure you received the real vaccine... however, what if you have not?

[Diomedes]

I cannot like this development enough. Huge deal.

[GanonsGrin]

https://apple.news/APBJR6utzRUiqOc38e2Prrw

Pfizer just got full FDA approval!!

[Diomedes]

Since there are a ton of questions people have about the Delta variant and what's up with that, I did this video last week, if anyone is curious about the evolutionary dynamics of what's going on. It's long-ish. Sorry.

[Tracker]

i would like to hope its 2 separate things as well, i didn't have much of a reaction to either shot, so now i wonder if i was lucky, or i had help,

i have a pretty good channel to get ahold of my doc so ill make sure to bring this one up to him.

[Diomedes]

I don’t *think* so, but I’m not 100% sure. Often, a genetic condition is the result of a slight change to a protein that a virus or parasite happens to use or interact with to infect your cells, and if it’s a little different, successfully infecting is harder. Think like sickle cell and malaria, for example. That’s unrelated to your immune system recognizing and preparing for that same virus. But that’s in general, I can’t say specifically for your case.

Edit: I misread your post, sorry. I don’t think the medication would effect your immune response, but check with your doctor to be sure. But it’s probably analogous to being vaccinated against a bacterial infection vs taking antibiotics. Just two separate things.

[Tracker]

so here's a new one that just popped up for me

it would seem that people taking fenofibrate have a reduced risk of infection
https://www.frontiersin.org/articles...21.660490/full

as someone with genetic hypertriglyceridemia and a regular taker of this medication for awhile, would that affect my vaccine?

(me making sure I understand the vaccine properly)
mRNA vaccines, like the one from Pfizer that I have, uses the mRNA signature of covid to make your body produce the correct covid proteins (as opposed to lab made proteins) and your body learns to make the antibodies based off those proteins.

if someone's medication accidentally gives them an advantage fighting it off on its own, wouldn't that have an effect on their body to produce the correct proteins from the vaccine?

[Diomedes]

That's much lower than the few studies I've seen out there, but maybe something was published in the last week or so. Most data I've seen were in the 80% range, and that was for over-65s, so probably better for younger.

Also, a lot of these write-ups in non-scientific publications, and even in popular-level science magazines, are conflating antibody levels with efficacy, which you can't do. Two different things. So like if the one-month antibody levels are one hundred times the threshold for "has neutralizing antibodies", and that drops by half at month 6...that's still fine. So make sure you read the original studies, and all the fine print.

[boarder2k7]

Not sure if this helps but, I got the J&J back in April and got my first shot of pfizer a few weeks ago. I'm going to get my 2nd dose tomorrow. J&J, I had no after effects. Pfizer, I felt under the weather, I didnt have to work so I slept the next day. I probably could have stayed up and worked though it if I had to.

I got the Pfizer shot just because. California is trying to pay people to get vaccinated so I figured I was not taking away from someone by double dosing. I didn't know there was any concerns with J&J efficacy until after I got the Pfizer. Unless this 2nd dose kills me or there is any announcement of harm of getting multiples, I plan on getting the Moderna shots in november. If I end up travelling overseas, I would consider getting the other vaccines not available in the US if I could.

I'm interested in how the second goes for you. I got Moderna first round, and with how delta is looking I'll say doubling up is looking more and more attractive....

It's not any of my business, but why are you "collecting" (for lack of a better word) the shots? Don't they all do basically the same thing?

Pokemon mentality, gotta catch em all!

From what I've seen there is evidence that an additional shot will further increase immune response and it may make you less susceptible to breakthrough infections.

[Brokeass_baller]

It's not any of my business, but why are you "collecting" (for lack of a better word) the shots? Don't they all do basically the same thing?

[ta2maki]

Not sure if this helps but, I got the J&J back in April and got my first shot of pfizer a few weeks ago. I'm going to get my 2nd dose tomorrow. J&J, I had no after effects. Pfizer, I felt under the weather, I didnt have to work so I slept the next day. I probably could have stayed up and worked though it if I had to.

I got the Pfizer shot just because. California is trying to pay people to get vaccinated so I figured I was not taking away from someone by double dosing. I didn't know there was any concerns with J&J efficacy until after I got the Pfizer. Unless this 2nd dose kills me or there is any announcement of harm of getting multiples, I plan on getting the Moderna shots in november. If I end up travelling overseas, I would consider getting the other vaccines not available in the US if I could.

[Diomedes]

No idea, but I'm just gonna copy what I said above: "I have no idea how all this impacts J&J. For what it's worth, J&J is less effective at reducing the risk of infection (still really good, just not *as good* as pfizer or moderna), but importantly, it is basically just as good at reducing hospitalization and death. And that's what matters, at the end of the day. If we turn this thing into a mild flu or a bad cold...that's actually okay."